Top 5 Over The Counter Fertility Drugs [Pills to Get Pregnant & Twins]

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According to research conducted by the Center for Disease Control (CDC), 12% of women are struggling to conceive or carry the pregnancy to term.

Due to such fertility issues, there are a variety of prescribed fertility treatment kits. A number of such kits are seemingly expensive for a majority of women to acquire. OTC or over the counter fertility drugs and pills work equally well and are quite affordable.

So, what is the best OTC fertility drug/supplement you can buy today to help you conceive?

5 best OTC fertility drugs that work

These are medications bought at a pharmaceutical store or online without prior prescription from a doctor. There are many reasons as to why most people prefer this type of medication.

First, these formulas are available in pill form compared to those most administered by injection.

Secondly, they are readily available without the hustle of prescription from your doctor. Here are the best OTC fertility drugs and pills you can buy this year.

There are a variety of fertility medications sold without a prescription. Here are the common:



FertilAid is known to be one of the best over the counter fertility drugs on the market today, competing Clomid-based supplements fiercely. It will do two things:

  • Regulate your cycle for women who have difficulty conceiving due to irregular menstrual cycle.
  • Act as a superb prenatal vitamin, meaning you can cut your budget on those as soon as you get pregnant.

The supplement is natural and also available for men as well. According to the manufacturer, this is good for women with irregular menstrual cycles, causing infertility.

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Eu Natural CONCEPTION Fertility Prenatal Vitamins

Eu Natural CONCEPTION Fertility Prenatal Vitamins

Inconsistent cycles are the major cause of infertility in women. To make it worse, when your periods come, they are very painful. Eu Natural’s OTC fertility pills can solve that and improve the quality of your ovulation to increase your chances of conceiving.

The 100% natural supplement formula contains vital fertility boosting ingredients, including Myo-Inositol, Vitex Chaste Tree Berry, and Folate Folic Acid, etc.

While fertility pills and drugs can help you conceive even twins easily, you should be cautious about taking them, especially if you are on other medications such as those of PCOS.

You should also consult your doctor before taking these even though they are non-prescription drugs to prevent severe side effects.

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Vitex woman’s dietary supplement

Nature's Way Vitex Chaste Tree

This is yet another widely used over the counter fertility drug. It can also be referred to as chaste berry, as it of the natural extract and is ideal for those women with short luteal phase (Period after ovulation and period).

  • It also prevents miscarriages and balances reproductive hormones.
  • One can also choose to take vitex with other fertility enhancing supplements such as calcium.

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Cassanovum Original Root Extract & Folic Acid Capsules

Nature's Way Vitex Chaste Tree

Also known as folate, folic acid has great fertility benefits. Folic helps the body produce new cells. It plays a major role in the conception and also prevents the baby from suffering any tubal or brain-related congenital disabilities.

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Folate is available as an antenatal vitamin but can also be taken by women who would love to boost their fertility with an OTC fertility drug or medication.

Other options that may need prescription include:


Also known as Glucophage, this drug is widely used by diabetic patients. It works by reducing the amount of insulin in the body. This drug can be used by women with Polycystic ovarian syndrome (PCOS) who are often insulin-resistant.

  • Additionally, metformin can be used to reduce the chances of miscarriage in women with a history of abortions and miscarriages.

It is sold as a pill of 500 milligrams. It should be taken once every day for a month. Its side effects are gastrointestinal –related. Occasionally one might experience some headache, which is normal.

Do fertility drugs work?

Fertility enhancing pills are medications that cause the body to release hormones that initiate and control the process of ovulation. Ovulation is the egg releasing process from the ovaries. The success rate depends on the drug itself.

For example, the success rate of Clomid

About 80 percent of women who take clomiphene ovulate in the first three months of treatment. Of them, 30 to 40 percent conceive by their third treatment cycle. (Source: Baby Center)

Most non-prescription pills are based on clomiphene (Clomid).

Clomid treatments (Serophene)

Popularly known as Clomid, Serophene is an estrogen antagonist. It blocks the actions of the hormone estrogen, enabling the endocrine system to produce gonadotropin-releasing hormone (GnRH).

  • Together with GnRH, luteinizing hormone and follicle-stimulating hormone are also released.
  • The primary role of these hormones is to trigger the egg-making process by the ovaries.

Clomid-based pills are by far the most popular in the market today. It is mainly used to treat infertility and sub-fertility – when you fail to conceive in the first year of trying.

Studies have shown that approximately 80% of women will start ovulating normally and significantly increase their chances of getting pregnant. Surprisingly, Clomid can also help men with fertility problems.

Clomid success rate:

80% of women on Clomid treatment will successfully ovulate and 10 to 12 percent will conceive per cycle. Therefore, the pregnancy rates are quite impressive.

Serophene is available in a dose of 50 milligrams on a prescription. You are to take a tablet each day for five days as a starting dose. Ovulation should start about a week after your last pill.

The dosage could be altered if the initial one does not work. You can take up to 150 milligrams daily for a month.

  • After ovulation, Clomid should be discontinued for about 6 months to give room for pregnancy to occur.
  • If no pregnancy occurs after 6 months, you will need to seek medical advice or try another drug.

When taking Clomid, you are likely to experience hot flashes, nausea, light-headedness, and bloating. All these symptoms are usually mild, and enough rest will make you feel better.

Additionally, Clomid may cause your vaginal mucus to thicken, hindering sperm penetration. Similarly, with such changes, you may be unable to tell your exact ovulation time.

Studies show that about 82 percent of women who use Clomid ovulate, and about 41 percent of them get pregnant. The majority of pregnancies occur from the second cycle. It is one of the best over the counter fertility drug to give a try.

Types on the market

Do OTC fertility pills for getting twins to work? There are two types of fertility-enhancing drugs, namely:

1. Oral fertility pills

These types of drugs are mostly sold over the counter. They are usually accompanied by fewer side effects to none. Common examples include vitex and Clomid.

2. Hormonal injectables

These types of drugs are taken into consideration when an oral fertility pill fails to work. They are recommended to trigger ovulation as in Polycystic Ovarian Syndrome (PCOS). The dose of such drugs varies depending on the fertility issues at hand.

  • The majority of these drugs are injected under the skin, while the rest are injected into the muscles.

The injections are usually recommended from the third day after your period. You are then to continue using them for the next 12 days. These drugs have a high success rate to help you get pregnant.

Research shows that about 50 percent of women who do not ovulate have a chance of becoming pregnant with one of the following injectables:

  • Follicle-stimulating hormone shots

These drugs work by initiating the growth of eggs in the ovaries.

  • Gonadotropin-releasing hormone injectable

These drugs trigger the release of follicle-stimulating hormone and luteinizing hormone. Both are essential for lengthening the period after ovulation and your period.

Are these pills effective?

Over the counter, drugs are effective. The only difference is that with these drugs, you do not need a doctor’s prescription to purchase them. However, you should be careful when purchasing over the counter fertility drugs.

Always check for the expiry date. If, for instance, a drug is expired, then its effectiveness is compromised. Again, take the correct dosage for better results. An underdose may not bring about the desired results.

Can I take them to have twins?

Do over the counter fertility drugs increase chances of multiples? Yes. Some women who used over the counter drugs reported conceiving multiples. Clomid, for example, when used properly, increases a woman’s chance to conceive twins by 45 percent.

Other natural fertility supplements


Heparin is an anti-coagulant. It works to prevent blood mother-child blood coagulation, especially for those negative rhesus mothers carrying positive rhesus fetus. One of the most common causes of inter-uterine fetal death is blood coagulation.

Rhesus is a term used to mean an antigen. Women who happen to be rhesus negative may pose a danger to their fetus if they happen to be of positive Rhesus factor.

  • Heparin works to protect clamping together of the two types of blood hence reduces the chances of miscarriages.


Also known as acetate, antagon works by preventing early ovulation. It also causes prolonged ovulation increasing a woman’s chances of conceiving. This drug has mild side effects, including a headache, abdominal pain, and nausea.

What are the risks involved?

Most of these drugs are safe to use. Studies have not shown any major risk to worry about. However, there are chances that one could conceive multiples. Multiple pregnancies are associated with complications such as prematurity and abortion.

Natural fertility remedies

Besides over the counter conventional fertility drugs, some natural remedies are quite useful in increasing fertility. Here are the best common remedies to give a try:

1. Evening Primrose oil

Primrose oil has been known for centuries to help with fertility issues. It works by improving vaginal mucus to protect the sperm during fertilization. Cervical mucus is essential in propelling the sperm to the egg, hence making it easier for fertilization to occur.

  • A tablespoon of this natural remedy once daily for about a month will increase one’s chances of becoming pregnant.

2. Red raspberry leaves

Pregnancy is impossible without implantation. Implantation is the attachment of a fertilized egg to the uterine lining, for growth and development.

Raspberry has been used for centuries to help nourish the uterine lining for proper implantation. It strengthens the uterine walls and reduces the chances of a miscarriage.

This remedy is best for those women with a prior history of miscarriages. It can be taken twice in a day. Glass in the morning on an empty stomach and another before bed.

3. Black cohosh

Black Cohosh is a natural fertility remedy suitable for developing healthy eggs. It is also available in supplement form and can cure several menstrual –cycle abnormalities.

It can be bought over the counter at an affordable price. Its side effects include nausea and diarrhea, but will be mild and fade away after 2-3 days.

In summary, here are ways to increase your chances of getting pregnant.

Getting Pregnant
How to increase your chances of getting pregnant


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